New agent targets chronic idiopathic constipation
نویسندگان
چکیده
منابع مشابه
Severe chronic constipation of young women: 'idiopathic slow transit constipation'.
A series of 64 women complaining of severe constipation is described, in each of whom delayed elimination of markers from the colon was demonstrated but a barium enema was normal. All completed a detailed questionnaire and the responses are compared with those obtained in an age-matched series of healthy women with no bowel complaint. In each group 40 women also recorded in a manner suitable fo...
متن کاملLinaclotide: A New Option for the Treatment of Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation in Adults
Chronic idiopathic constipation (CC) and irritable bowel syndrome with predominant constipation (IBS-C) are the 2 most common conditions among functional gastrointestinal disorders. Despite current multiple therapeutic options, treatment remains challenging and dissatisfactory to many patients. Linaclotide is a novel therapeutic agent, which is a guanylate cyclase receptor agonist that stimulat...
متن کاملChronic constipation: no more idiopathic, but a true neuropathological entity
Chronic constipation is still considered a functional or idiopathic disorder. However, in recent years there is evidence that its pathopysiological grounds may be actually due to a complex system of abnormalities of the enteric nervous system of these patients. In particular, as reported in this review, the enteric glial cells seem to be constantly involved in constipated patients, suggesting t...
متن کاملChronic idiopathic slow transit constipation: pathophysiology and management.
OBJECTIVE Patients with idiopathic slow-transit constipation comprise a small proportion of the total population complaining of constipation. The purpose of this review is to present an update of pathophysiology of this disorder and its application in clinical management. METHODS Medline was used to search English language articles published up to the end of September 2002 on the subject of s...
متن کاملOutcome of behavioural treatment for idiopathic chronic constipation.
BACKGROUND/AIM Behavioural therapy is effective in patients with chronic intractable constipation despite standard treatment, but long-term results in unselected patients are unclear. This study investigates the effects of behavioural therapy on symptoms, subjective well-being, and the physical and mental quality of life. METHODS Patients who had failed standard care for idiopathic chronic co...
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ژورنال
عنوان ژورنال: Pharmacy Today
سال: 2017
ISSN: 1042-0991
DOI: 10.1016/j.ptdy.2017.02.014